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SML3802

ARN-3236

≥98% (HPLC)

Synonym(s):

3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine, 3-(2,4-Dimethoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridin, ARN 3236, ARN3236

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
585,00 PLN
25 mg
Please contact Customer Service for Availability
2.350,00 PLN

About This Item

Empirical Formula (Hill Notation):
C19H16N2O2S
CAS Number:
Molecular Weight:
336.41
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

585,00 PLN


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1cc(cc1)c2c3c([nH]cc3c4c(cc(cc4)OC)OC)ncc2

InChI

1S/C19H16N2O2S/c1-22-13-3-4-15(17(9-13)23-2)16-10-21-19-18(16)14(5-7-20-19)12-6-8-24-11-12/h3-11H,1-2H3,(H,20,21)

InChI key

WEHOIIGXTMKVRG-UHFFFAOYSA-N

Biochem/physiol Actions

ARN-3236 is an orally active, ATP-competitive, SIK2-selective salt-inducible kinase inhibitor (IC50 = 21.63 nM/SIK1, <1 nM/SIK2, 6.63 nM/SIK3) that suppresses cellular SIK2 activity (by 58% at 1 μM; SKOv3-SIK2 cells, 48 h) with high selectivity over >456 kinases. ARN-3236 effectively suppresses SIK2-dependent growth of ovarian cancer cultures (IC50 = 0.8-2.6 μM in 10 lines, 72 h) and in murine xenograft models in vivo (30, 60, 100 mg/kg/day p.o.). In addition, ARN-3236 sensitizes ovarian cancer cells to paclitaxel in vitro and in vivo. ARN-3236 completes the SIK1-selective HG-9-91-01 (SIK1/2/3 IC50 = 0.6/6.6/9.6 nM) in probing SIKs-mediated cellular signaling events.
Orally active, ATP-competitive, highly potent and selective SIK2 inhibitor with anti-ovarian cancer efficacy in vitro and in vivo.

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This Item
SML3792SAB1305168CY10345573
description

≥98% (HPLC)

description

≥96% (HPLC)

description

affinity isolated antibody, buffered aqueous solution

description

L × W 110 mm × 20 mm, grade 3236, gray cellulose (50 double pleats), hydrophilic, pack of 500 ea

form

powder

form

powder

form

buffered aqueous solution

form

-

assay

≥98% (HPLC)

assay

≥96% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

color

white to beige

color

white to beige

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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