SML3623
DSRM-3716
≥98% (HPLC)
Synonym(s):
5-Iodoisoquinoline, DSRM 3716, DSRM3716
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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Please contact Customer Service for Availability | 345,00 PLN |
100 mg | Please contact Customer Service for Availability | 1.380,00 PLN |
About This Item
Empirical Formula (Hill Notation):
C9H6IN
CAS Number:
Molecular Weight:
255.06
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, yellow to light brown
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
Ic1c2c(cncc2)ccc1
InChI key
CUILFTFMBBGSFT-UHFFFAOYSA-N
Biochem/physiol Actions
DSRM-3716 is a potent and selective SARM1 NADase inhibitor (NAD+ hydrolysis IC50 = 75 nM using recombinant SARM1 SAM-TIR construct) that recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy (EC50 = 2.1/1.9 µM by fragmentation/NfL release using mouse DRG neurons; 81/88% protection by 1/3 µM DSRM-3716 using human iPSC-derived motor neurons) or mitochondrial dysfunction (3-30 µM DSRM-3716 against 25 µM rotenone-induced injury; mouse DRG neurons). Mechanistically, DSRM-3716 undergoes base exchange with the nicotinamide (NAM) moiety of nicotinamide adenine dinucleotide (NAD+) to yield the bona fide inhibitor 1AD.
Potent and selective SARM1 NADase inhibitor that protects axons from degeneration induced by axotomy or mitochondrial dysfunction.
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This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description - | description - |
| assay ≥98% (HPLC) | assay - | assay - |
| form powder | form liquid | form powder |
| Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear (Warmed) | solubility - | solubility H2O: 20 mg/mL, clear |
| color , yellow to light brown | color - | color white to beige |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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