SML3516
EN106
≥98% (HPLC)
Synonym(s):
2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 275,00 PLN |
25 mg | Please contact Customer Service for Availability | 1.110,00 PLN |
About This Item
Empirical Formula (Hill Notation):
C13H13ClN2O3
CAS Number:
Molecular Weight:
280.71
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(CCl)N(C1=CC2=C(OCCO2)C=C1)CCC#N
InChI key
GLDJSVHDOXCYPT-UHFFFAOYSA-N
Biochem/physiol Actions
Cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B
EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear (warmed) | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 10 mg/mL (clear solution) |
| color white to beige | color white to beige | color faint brown to very dark brown-red | color white to beige |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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