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SML3458

KL-11743

≥98% (HPLC), Class I glucose transporter inhibitor, powder

Synonym(s):

2-(3-(6-Ethoxy-4-((4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenyl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide, 2-[3-[6-Ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
378,00 PLN
25 mg
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1.510,00 PLN

About This Item

Empirical Formula (Hill Notation):
C30H30N6O3
CAS Number:
Molecular Weight:
522.60
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

378,00 PLN


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Product Name

KL-11743, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

KL-11743 is an orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo. It induces aspartate accumulation and increases mitochondrial metabolism. KL-11743 specifically inhibits the growth of tumors containing truncated the tricarboxylic acid (TCA) cycle due to mutations inactivating succinate dehydrogenase. Inhibition of glucose uptake by KL-11743 may synergize with therapies that induce oxidative stress (synthetic lethality).
orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo

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This Item
SML0621CB_13082233
vibrant-m

OX-117

description

≥98% (HPLC)

description

≥98% (HPLC)

description

NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA.

form

powder

form

powder

form

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−196°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

-

color

white to beige

color

white to beige

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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