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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 378,00 PLN |
25 mg | Please contact Customer Service for Availability | 1.510,00 PLN |
About This Item
Empirical Formula (Hill Notation):
C30H30N6O3
CAS Number:
Molecular Weight:
522.60
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Product Name
KL-11743, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
KL-11743 is an orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo. It induces aspartate accumulation and increases mitochondrial metabolism. KL-11743 specifically inhibits the growth of tumors containing truncated the tricarboxylic acid (TCA) cycle due to mutations inactivating succinate dehydrogenase. Inhibition of glucose uptake by KL-11743 may synergize with therapies that induce oxidative stress (synthetic lethality).
orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo
1 of 1
This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA. |
| form powder | form powder | form - |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −196°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility - |
| color white to beige | color white to beige | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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