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SML3361

Imepitoin

≥98% (HPLC)

Synonym(s):

1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one, 1-(4-Chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one, AWD 131-138, AWD131-138, ELB138

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Size/SKUAvailabilityPrice
10 mg
Please contact Customer Service for Availability
405,00 PLN
50 mg
Please contact Customer Service for Availability
1.630,00 PLN

About This Item

Empirical Formula (Hill Notation):
C13H14ClN3O2
CAS Number:
Molecular Weight:
279.72
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

405,00 PLN


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1N=C(CN1C2=CC=C(C=C2)Cl)N3CCOCC3

InChI

1S/C13H14ClN3O2/c14-10-1-3-11(4-2-10)17-9-12(15-13(17)18)16-5-7-19-8-6-16/h1-4H,5-9H2

InChI key

IQHYCZKIFIHTAI-UHFFFAOYSA-N

Biochem/physiol Actions

Benzodiazepine-binding site GABAA receptor partial positive allosteric modulator (PAM) with in vivo efficacy in animal models of seizure and epilepsy.
Imepitoin (AWD 131-138; ELB 138) is a g-aminobutyric acid A (GABAA) receptor partial positive allosteric modulator (PAM) that targets the benzodiazepine (BZD)-binding site at the α/γ2-interface. Imepitoin enhances GABA current (% response/[GABA] alone in µM/receptor complex = 320/3/α1β2γ2, 310/25/α1β3γ2, 460/8/α2β2γ2, 590/12/α3β2γ2 and 290/3/α5β2γ2 using Xenopus oocytes expressing respective rat receptor complex) with ~2% the potency and 17-27% the efficacy of diazepam toward α1β2γ2. Imepitoin exhibits in vivo therapeutic efficacy in animal models of seizure and epilepsy.

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This Item
1A01610PHR3612SML0100
description

≥98% (HPLC)

description

Pharmaceutical Analytical Impurity (PAI)

description

certified reference material, pharmaceutical secondary standard

description

≥98% (HPLC)

form

powder

form

-

form

-

form

powder

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

solubility

DMSO: ≥3 mg/mL

color

white to beige

color

-

color

-

color

white to tan


pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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