SML3338

NF-56-EJ40

≥98% (HPLC)

• Synonym(s): 2-(2-(4′-((4-Methylpiperazin-1-yl)methyl)biphenyl-3-ylcarboxamido)phenyl)acetic acid, 2-(2-(4′-((4-methylpiperazin-1-yl)methyl)-[1,1′-biphenyl]-3-carboxamido)phenyl)acetic acid, 2-[[[4′-[(4-Methyl-1-piperazinyl)methyl][1,1′-biphenyl]-3-yl]carbonyl]amino]-benzeneacetic acid
• Empirical Formula (Hill Notation): C₂₇H₂₉N₃O₃
• CAS Number: 2380230-73-7
• Molecular Weight: 443.54
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD32263439
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

High-affinity, human-selective SUCNR1 (GPR91) antagonist that blocks human GPR91-mediated cellular signaling with no activity towards rat species.

NF-56-EJ40 is a high-affinity, potent and human species-selective succinate receptor SUCNR1 (GPR91) antagonist (human GPR91 Ki/KD = 17.4/33 nM; GTPγS assay IC50 = 25 nM/human, >100 μM/rat). Extracellular succinate is reported to hyperpolarize M2 macrophages through GPR91-mediated Gq signaling, blockable by NF-56-EJ40 (1 μM) or Gq inhibitor YM-254890 (1 μM).

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable