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SML3312

SRI-41315

≥95% (HPLC), readthrough agent, powder

Synonym(s):

2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
525,00 PLN
25 mg
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2.120,00 PLN

About This Item

Empirical Formula (Hill Notation):
C22H19N3O2
CAS Number:
Molecular Weight:
357.41
UNSPSC Code:
51111800
NACRES:
NA.32
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated

525,00 PLN


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Product Name

SRI-41315, ≥95% (HPLC)

Quality Segment

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

O=C1N(C2=CC=CC=C2)C(C3CCC3)=NC4=C1C(C5=CC=CC=C5N4C)=O

Biochem/physiol Actions

Cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon
SRI-41315 is a cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon and allows translation elongation to continue in the correct reading frame and generate a full-length protein. SRI-41315 induces the translational pause that occurs at premature termination codons by depleting eRF1 protein levels through a proteasome-mediated degradation pathway. SRI-41315 restores CFTR expression and function in in immortalized and primary human bronchial epithelial cells.

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form

powder

form

powder

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

-10 to -25°C

storage temp.

room temp

storage temp.

−20°C

storage temp.

−20°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

-

solubility

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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