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SML3250

HIF-1α stabilizer 1a

≥98% (HPLC)

Synonym(s):

Bis[2-(2-pyridinyl-kN)phenyl-kC](4,7-dimethoxy-1,10-phenanthroline-kN1, kN10)iridium(III) hexafluorophosphate (1:1), Ir(III) complex 1a

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
377,00 PLN
25 mg
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1.520,00 PLN

About This Item

Empirical Formula (Hill Notation):
C36H28O2IrN4·PF6
Molecular Weight:
885.81
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder

377,00 PLN


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Cell penetrant stabilizer of hypoxia-inducible factor-1α (HIF-1α)
HIF-1α stabilizer 1a, a cyclometalated iridium(III) complex, is a cell penetrant stabilizer of hypoxia-inducible factor-1α (HIF-1α) that binds to Von Hippel-Lindau (VHL) tumor suppressor and inhibits the VHL–HIF-1α interaction thereby preventing HIF-1α degradation. HIF-1α stabilizer 1a induces HIF-1α accumulation in cells and activates HIF-1α mediated gene expression. It significantly accelerates wound closure in both normal.

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H6411400087H6536
description

≥98% (HPLC)

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~1 mg/mL, clone OZ12, purified immunoglobulin, buffered aqueous solution

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The HIF-2α Translation Inhibitor, also referenced under CAS 882268-69-1, controls the biological activity of HIF-2α. This small molecule/inhibitor is primarily used for Cell Structure applications.

description

~1 mg/mL, clone H1α67, purified immunoglobulin, buffered aqueous solution

form

powder

form

buffered aqueous solution

form

solid

form

buffered aqueous solution

assay

≥98% (HPLC)

assay

-

assay

≥95% (sum of two isomers)

assay

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMSO: 5 mg/mL

solubility

-

color

white to beige

color

-

color

amber

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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