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SML3112

cis-22a

≥98% (HPLC)

Synonym(s):

1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine, trifluoroacetate (1:2), cis-1-(4-(3-Methylphenyl)cyclohexyl)-4-((pyridin-4-yl)methyl)piperazine, trifluoroacetate (1:2)

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
459,00 PLN
25 mg
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1.850,00 PLN

About This Item

Empirical Formula (Hill Notation):
C22H29N3 · 2CF3CO2H
CAS Number:
Molecular Weight:
563.53
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

459,00 PLN


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=CC=CC([C@H]2CC[C@@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

InChI key

UMKPISXYUQWXJJ-XWOHEVPJSA-N

Biochem/physiol Actions

Potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor that selectively inhibits the growth of TrpV6-expressing, but not TrpV6-negative cancer cultures.
cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2+ influx IC50 = 320 nM; hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets. cis-22a selectively inhibits the growth of TrpV6-expressing breast cancer T47D (IC50 = 25 μM), but not TrpV6-negative ovarian carcinoma SKOV3 cultures (IC50 >50 μM).

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vibrant-m

MH-22A

description

≥98% (HPLC)

description

≥98% (HPLC)

description

affinity isolated antibody

description

NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA.

form

powder

form

powder

form

buffered aqueous solution

form

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−196°C

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL (clear solution; warmed)

solubility

-

solubility

-

color

white to beige

color

white to beige

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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