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SML1901

ML348

≥98% (HPLC)

Synonym(s):

ML 348, ML-348, N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)-1-piperazinyl]acetamide

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
459,00 PLN
25 mg
Please contact Customer Service for Availability
1.840,00 PLN

About This Item

Empirical Formula (Hill Notation):
C18H17ClF3N3O3
CAS Number:
Molecular Weight:
415.79
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

459,00 PLN


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(c(cc1)Cl)NC(=O)CN2CCN(CC2)C(=O)c3[o]ccc3

InChI

1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26)

InChI key

OXKNHBBDOIMFFQ-UHFFFAOYSA-N

Biochem/physiol Actions

ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.

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This Item
SML1205G7423S5326
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC), white to off-white, powder

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: >20 mg/mL

color

white to beige

color

white to light brown

color

white to off-white

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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