SML1778

SR0987

≥98% (HPLC)

• Synonym(s): 2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propanyl)phenyl)benzamide
• Empirical Formula (Hill Notation): C₁₆H₁₀ClF₆NO₂
• CAS Number: 303126-97-8
• Molecular Weight: 397.70
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: FC(F)(F)C(O)(C(F)(F)F)c1ccc(cc1)NC(=O)c2c(cccc2)Cl
• InChI key: IZVBONMVWLTLNT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency toward T-cell-specific retinoic acid receptor-related orphan receptor ROR?t (EC₅₀ ~800 nM in cell-based reporter assays) by targeting an allosteric pocket within the RORγt ligand-binding domain (LBD). In addition to upregulating RORγt target gene IL17A expression, SR0987 is shown to simultaneously downregulate surface immune checkpoint protein PD-1 expression by a yet unidentified mechanism among ex vivo differentiated murine TH17 cells, as well as PMA/ionophore-stimulated human Jurkat T cells and murine EL4 T lymphocytes.

SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H410
• pcodes: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable