SML1571

S14161

≥98% (HPLC)

• Synonym(s): 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran, 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene, Pichromene
• Empirical Formula (Hill Notation): C₁₇H₁₄FNO₄
• CAS Number: 883046-50-2
• Molecular Weight: 315.30
• NACRES: NA.77
• PubChem Substance ID: 329825969
• UNSPSC Code: 12352200
• MDL number: MFCD00112055
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated, protect from light

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated, protect from light
• color: white to beige
• storage temp.: −20°C
• SMILES string: FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2
• InChI: 1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3
• InChI key: BFZXDHIUPNWOMT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315
• Precautionary Statements: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3