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SML1522

Doxofylline

≥98% (HPLC)

Synonym(s):

7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione, 7-(1,3-Dioxolan-2-ylmethyl)theophylline

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Size/SKUAvailabilityPrice
50 mg
Please contact Customer Service for Availability
377,00 PLN

About This Item

Empirical Formula (Hill Notation):
C11H14N4O4
CAS Number:
69975-86-6
Molecular Weight:
266.25
NACRES:
NA.77
PubChem Substance ID:
329825939
UNSPSC Code:
12352200
MDL number:
MFCD00865218
Assay:
≥98% (HPLC)
Form:
powder

377,00 PLN

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CN1C2=C(N(CC3OCCO3)C=N2)C(N(C)C1=O)=O

InChI

1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3

InChI key

HWXIGFIVGWUZAO-UHFFFAOYSA-N

General description

Doxofylline is a novel xanthine derivative comprising of dioxolone group.

Application

Doxofylline has been used as a phosphodiesterase (PDE) inhibitor to study its protective effects on lipopolysaccharides (LPS)-induced inflammatory response in human pulmonary bronchial epithelial cells. It has also been used to study its interaction with bovine serum albumin (BSA).

Biochem/physiol Actions

Doxofylline acts and as a non-selective phosphodiesterase (PDE) inhibitor and exhibits anti-inflammatory activity. It has the potential to treat chronic obstructive pulmonary disease (COPD).
Doxofylline (also known as doxophylline) has antitussive and bronchodilator effects. Doxofylline is used clinically in the treatment of asthma. Doxofylline has similar efficacy to theophylline, but unlike theophylline or other xanthines has little affinity for adenosine receptors and does not produce stimulant effects and has significantly fewer side effects.

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This Item
E2500000
Doxofylline ≥98% (HPLC)

Sigma-Aldrich

SML1522

Doxofylline

Etofylline European Pharmacopoeia (EP) Reference Standard

E2500000

Etofylline

description

≥98% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

assay

≥98% (HPLC)

assay

-

form

powder

form

-

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

-

color

white to beige

color

-

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Questions

  1. Is it a secondary reference standart?

    1 answer

    1. This product is not a secondary reference standard. It is intended for use in general laboratory research applications. Currently, this compound is not available as secondary reference standard.

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