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SML1509

MK6-83

≥98% (HPLC)

Synonym(s):

5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C16H20N2O2S2
CAS Number:
Molecular Weight:
336.47
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(Nc2c(cccc2)N3CCCCC3)c1[s]c(cc1)C

InChI

1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3

InChI key

IRGYSXZCDAWOOC-UHFFFAOYSA-N

Biochem/physiol Actions

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel.
MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.
MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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