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KU-55933

Name: KU-55933
Brand: SIGMA

≥98% (HPLC), Ataxia telangiectasia (A-T) mutated (ATM) kinase inhibitor, powder

Synonym(s):

2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-Pyran-4-one, 2-(Morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₁₇NO₃S₂

CAS Number:

587871-26-9

Molecular Weight:

395.49

UNSPSC Code:

12352200

PubChem Substance ID:

329825484

NACRES:

NA.77

MDL number:

MFCD08276985

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

Pricing and availability is not currently available.

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Properties

Product Name

KU-55933, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5

InChI

1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

InChI key

XRKYMMUGXMWDAO-UHFFFAOYSA-N

Description

Application

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.

Biochem/physiol Actions

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC₅₀ = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase.

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This Item	118500	A1106	ZRB1376
Sigma-Aldrich SML1109 KU-55933	Sigma-Aldrich 118500 ATM Kinase Inhibitor	Sigma-Aldrich A1106 Anti-ATM antibody,Mouse monoclonal	Sigma-Aldrich ZRB1376 Anti-ATM Antibody, clone 4N19, ZooMAb^® Rabbit Monoclonal
description ≥98% (HPLC)	description -	description clone MAT3-4G10/8, purified from hybridoma cell culture	description recombinant, expressed in HEK 293 cells
form powder	form -	form PBS solution	form lyophilized
assay ≥98% (HPLC)	assay -	assay -	assay -
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. -	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL, clear	solubility -	solubility -	solubility -
storage condition desiccated	storage condition -	storage condition -	storage condition -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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