SR1555

Name: SR1555
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

1,1,1,3,3,3-Hexafluoro-2-(4′-((1-(acetyl) piperazine) methyl)-[1,1′-biphenyl]-4-yl)propan-2-ol

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₂F₆N₂O₂

CAS Number:

1386439-51-5

Molecular Weight:

460.41

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

Description

Biochem/physiol Actions

SR1555 is a selective RORγ inverse agonist that inhibits the development and function of TH17 cells, a subset of T cells that have been implicated in the pathology of several autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. SR1555 also increases the frequency of T regulatory cells, an effect not seen with previously described RORγ ligands.

SR1555 is a selective RORγ inverse agonist.

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This Item	SML1170	SML2037	SML0322
Sigma-Aldrich SML0765 SR1555	Sigma-Aldrich SML1170 SR2211	Sigma-Aldrich SML2037 SR2595	Sigma-Aldrich SML0322 SR1001
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 15 mg/mL, clear	solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear	solubility DMSO: >5 mg/mL
color white to beige	color white to beige	color white to faint brown	color white to beige