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Key Documents

SML0393

Sigma-Aldrich

QNZ46

≥98% (HPLC)

Synonym(s):

4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C24H17N3O6
CAS Number:
Molecular Weight:
443.41
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (warmed; clear solution)

storage temp.

room temp

SMILES string

COc1ccc2N=C(\C=C\c3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O

InChI

1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+

InChI key

GNLVJIICVWDSNI-LFYBBSHMSA-N

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Show Differences

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This Item
GF32846722GF09253975GF10691298
Lead foil, 0.5m coil, thickness 0.1mm, as rolled, 99.95%

GF23031166

Lead

Lead foil, 1m coil, thickness 0.25mm, as rolled, 99.95%

GF32846722

Lead

Lead foil, 0.5m coil, thickness 0.5mm, as rolled, 99.95%

GF09253975

Lead

Lead foil, 0.5m coil, thickness 0.15mm, as rolled, 99.95%

GF10691298

Lead

manufacturer/tradename

Goodfellow 230-311-66

manufacturer/tradename

Goodfellow 328-467-22

manufacturer/tradename

Goodfellow 092-539-75

manufacturer/tradename

Goodfellow 106-912-98

assay

99.95%

assay

99.95%

assay

≥99.95%

assay

99.95%

mp

327.4 °C (lit.)

mp

327.4 °C (lit.)

mp

327.4 °C (lit.)

mp

327.4 °C (lit.)

resistivity

20.65 μΩ-cm

resistivity

20.65 μΩ-cm

resistivity

20.65 μΩ-cm

resistivity

20.65 μΩ-cm

bp

1740 °C (lit.)

bp

1740 °C (lit.)

bp

1740 °C (lit.)

bp

1740 °C (lit.)

Biochem/physiol Actions

QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC50 values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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