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SML0264

AEG 3482

≥98% (HPLC)

Synonym(s):

6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

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Size/SKUAvailabilityPrice
5 mg
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PLN 532.00

About This Item

Empirical Formula (Hill Notation):
C10H8N4O2S2
CAS Number:
Molecular Weight:
280.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

PLN 532.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3

InChI

1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)

InChI key

MQUYTXDAVCOCMX-UHFFFAOYSA-N

Biochem/physiol Actions

AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.[1]
AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.
AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML2472SML1806I6410
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

solid

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥15 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: ≥20 mg/mL, H2O: insoluble

color

faintly yellow to dark yellow

color

white to pink

color

white to light brown

color

yellow


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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