SML0228

Rc-Ome

≥98% (HPLC)

• Synonym(s): (2E)-3-(2-hydroxy-5-methoxyphenyl)-1-(4-methoxyphenyl)-2-Propen-1-one, trans-6,4′-dimethoxyretrochalcone
• Empirical Formula (Hill Notation): C₁₇H₁₆O₄
• CAS Number: 1073553-28-2
• Molecular Weight: 284.31
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: , light to dark yellow
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C

Description

Application

Rc-Ome may be used in GABA_A-mediated cell signaling studies.

Biochem/physiol Actions

Rc-OMe is a GABA_A PAM

Rc-OMe is a GABA_A PAM that distinguishes α₁β_2γ2s from α₁β₂ receptors. The compound has very weak potentiating effects on α₁β₂, but potentiates GABA-elicited currents of α₍₁₂₃₎β_2γ2s receptors, all with low μM EC₅₀s. Rc-OMe acts at a binding site that is distinct from BDZ, pentobarbital and loreclezole modulatory sites.

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Statements: H400
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable