SML0096

Cinnabarinic Acid

≥98% (HPLC), mGlu4R agonist, powder

• Synonym(s): 2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid, Cinnabaric acid
• Empirical Formula (Hill Notation): C₁₄H₈N₂O₆
• CAS Number: 606-59-7
• Molecular Weight: 300.22
• UNSPSC Code: 12352106
• PubChem Substance ID: 329825154
• NACRES: NA.25
• MDL number: MFCD18379297
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Cinnabarinic Acid, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: red to very dark red
• solubility: DMSO: ≥4 mg/mL
• storage temp.: 2-8°C
• SMILES string: NC1=C(C(O)=O)C2=Nc3c(OC2=CC1=O)cccc3C(O)=O
• InChI: 1S/C14H8N2O6/c15-10-6(17)4-8-12(9(10)14(20)21)16-11-5(13(18)19)2-1-3-7(11)22-8/h1-4H,15H2,(H,18,19)(H,20,21)
• InChI key: FSBKJYLVDRVPTK-UHFFFAOYSA-N

Description

Application

Cinnabarinic acid may be used in studies of the functions of components of the kynurenine metabolic pathway. It may be used to study it role as a metabotropic glutamate receptor (mGlu4R-specific) agonist.

Biochem/physiol Actions

Caspase Inducer; mGlu4R agonist

Cinnabarinic acid is a kynurenine pathway metabolite of tryptophan, produced by the oxidation of 3-Hydroxyanthranilic acid. Cinnabarinic acid leads to loss of mitochondrial respiration and apoptosis, and has also been shown to be an mGlu4R-specific agonist.

Caspase Inducer; mGlu4R agonist
Cinnabarinic acid (CA) connects between initiation of the kynurenine pathway and immune tolerance that is used to prevent neuroinflammation.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable