SML0084
IM-12
≥98% (HPLC)
Synonym(s):
3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 590,00 PLN 501,50 PLN |
About This Item
Empirical Formula (Hill Notation):
C22H20FN3O2
CAS Number:
Molecular Weight:
377.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
501,50 PLN
List Price590,00 PLNSave 15%Please contact Customer Service for Availability
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
yellow-orange
solubility
DMSO: ≥9 mg/mL
storage temp.
2-8°C
SMILES string
CN1C(=O)C(NCCc2ccc(F)cc2)=C(C1=O)c3c(C)[nH]c4ccccc34
InChI
1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
InChI key
ZKJAZFUFPPSFCO-UHFFFAOYSA-N
Biochem/physiol Actions
GSK-3β inhibitor
IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. It has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description - | description - | description - |
| form powder | form solid | form powder | form - |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥99% (TLC) | assay - |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. - |
| solubility DMSO: ≥9 mg/mL | solubility DMSO: 50 mg/mL | solubility DMSO or DMF: soluble | solubility - |
| storage condition desiccated | storage condition OK to freeze | storage condition - | storage condition - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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