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SCP0041

Sigma-Aldrich

[Ala28]-Amyloid β 25-35

≥95% (HPLC)

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1 MG
PLN 552.00
5 MG
PLN 1,900.00

PLN 552.00

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1 MG
PLN 552.00
5 MG
PLN 1,900.00

About This Item

Empirical Formula (Hill Notation):
C42H74N12O14S1
CAS Number:
173993-86-7
Molecular Weight:
1003.17
UNSPSC Code:
12352209
NACRES:
NA.32

PLN 552.00

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Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥68%

storage condition

protect from light

UniProt accession no.

P05067

storage temp.

−20°C

Gene Information

human ... APP(351)

Amino Acid Sequence

Gly-Ser-Asn-Ala-Gly-Ala-Ile-Ile-Gly-Leu-Met

General description

β-Amyloid peptides are a major component of the senile placques characteristic of the Alzheimer brain. Aβ (25-35) represents the region that aggregates during placque formation in Alzheimer′s disease and is a functional domain implicated in both neurotrophic and neurotoxic effects. Substitutions in this sequence can contribute to an understanding of structural characteristics related to membrane insertion, aggregation and protfibril formation with subsequent neurotoxic effects.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BB1138

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Hui-Hsu Gavin Tsai et al.
Proteins, 78(8), 1909-1925 (2010-03-17)
The mechanisms of interfacial folding and membrane insertion of the Alzheimer's amyloid-beta fragment Abeta(25-35) and its less toxic mutant, N27A-Abeta(25-35) and more toxic mutant, M35A-Abeta(25-35), are investigated using replica-exchange molecular dynamics in an implicit water-membrane environment. This study simulates the

Questions

1–2 of 2 Questions  

  1. How should the [Ala28]-Amyloid β 25-35 product, SCP0041 (CAS 173993-86-7), be dissolved or reconstituted?

    1 answer

    1. Solubility testing for this product has not been conducted. However, information from other competitors/vendors available online indicates the following solubility levels: 0.5 mg/mL in water and 2.5 mg/mL in 10% DMSO.

      Helpful?

  2. What is the solubility of the product for making stock solution. Is it soluble in water or not. Product name : [Ala28]- Amyloid beta 25-35, Catalogue no- SCP004, Quantity-5mg

    1 answer

    1. The solubility of this product is not determined. However, similar Amyloid β 25-35 products are soluble at 1 mg/ml in 1% acetic acid. In addition, various sources report that this material may be solubilized in the following:
      0.5 mg/mL in water
      2.5 mg/mL in 10% DMSO

      Helpful?

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