SRC (proto-oncogene, non-receptor tyrosine kinase) belongs to the Src family kinases (SFKs). It contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus. This gene is located on human chromosome 20q11.
Immunogen
The antiserum was produced against synthesized peptide derived from human Src around the phosphorylation site of Tyr418.
Immunogen Range: 386-435
Application
Anti-phospho-Src (pTyr418) antibody has been used in immunofluorescence.
Biochem/physiol Actions
SRC (proto-oncogene, non-receptor tyrosine kinase) controls early HIV-1 (human immunodeficiency virus 1) infection post-entry. This gene participates in fundamental physiological and pathological processes like carcinogenesis and tumor progression. Src kinase activity helps in the migration of endothelial cells.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular biology of the cell, 27(22), 3591-3600 (2016-11-05)
Investigation of heterogeneous cellular structures using single-molecule localization microscopy has been limited by poorly defined localization accuracy and inadequate multiplexing capacity. Using fluorescent nanodiamonds as fiducial markers, we define and achieve localization precision required for single-molecule accuracy in dSTORM images.
c-SRC protein tyrosine kinase regulates early HIV-1 infection post-entry
McCarthy SD, et al.
AIDS, 30(6), 849-858 (2016)
Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment.
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