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About This Item
Empirical Formula (Hill Notation):
C26H45NO4
CAS Number:
Molecular Weight:
435.64
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
NACRES:
NA.21
To inquire about this product S8326, please contact your local Merck office or dealer. Contact Technical Service
Quality Level
assay
≥98% (HPLC)
form
oil
color
colorless to light brown
storage temp.
2-8°C
SMILES string
CCCCCCCCCCCCCC#CC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C
InChI
1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m0/s1
InChI key
YGBSGZPIDCXNEH-QFIPXVFZSA-N
Application
SKI 5C was used to inhibit Sphingosine kinase 1 in SK-Hep1, HEK-293T cells.1
Biochem/physiol Actions
SKI 5C is a selective Sphingosine Kinase 1 (SPHK1) inhibitor.
SKI 5C is a sphingosine kinase 1 inhibitor.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form oil | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| color colorless to light brown | color white to beige | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Youmna Atieh et al.
Current biology : CB, 31(6), 1129-1140 (2021-01-06)
Extrusion is a mechanism used to eliminate unfit, excess, or dying cells from epithelial tissues. The initial events guiding which cells will be selectively extruded from the epithelium are not well understood. Here, we induced damage in a subset of
Meiyan Bao et al.
Liver international : official journal of the International Association for the Study of the Liver, 32(2), 331-338 (2011-11-22)
Sphingosine kinase 1 (SphK1), which phosphorylates sphingosine to sphingosine-1-phosphate (S1P), is overexpressed in various types of cancers, and may act as an oncogene in tumorigenesis. However, little is known about the precise role of the SphK1/S1P pathway in human liver
Sebastian Wurster et al.
Cell reports, 34(12), 108896-108896 (2021-03-25)
Severe and often fatal opportunistic fungal infections arise frequently following mucosal damage caused by trauma or cytotoxic chemotherapy. Interaction of fungal pathogens with epithelial cells that comprise mucosae is a key early event associated with invasion, and, therefore, enhancing epithelial
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S8326-5MG | 04061832449807 |
| S8326-25MG | 04061832449791 |



