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S0278

Sigma-Aldrich

(±)-Sotalol hydrochloride

≥98% (TLC), powder, β-Adrenoceptor antagonist

Synonym(s):

N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

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25 MG
PLN 436.00
100 MG
PLN 1,530.00

PLN 436.00

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25 MG
PLN 436.00
100 MG
PLN 1,530.00

About This Item

Empirical Formula (Hill Notation):
C12H20N2O3S · HCl
CAS Number:
959-24-0
Molecular Weight:
308.82
EC Number:
213-496-0
MDL number:
MFCD00242937
UNSPSC Code:
12352200
PubChem Substance ID:
24278689
NACRES:
NA.77

PLN 436.00

Please contact Customer Service for Availability
Request a Bulk Order

Product Name

(±)-Sotalol hydrochloride, ≥98% (TLC), powder

Quality Level

200

Assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

H2O: 20 mg/mL

originator

Bayer

SMILES string

Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1

InChI

1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

InChI key

VIDRYROWYFWGSY-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)

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Application

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts.[1] It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.[2]

Biochem/physiol Actions

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.[3]

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000354806
0000354807
0000351259
0000354806
0000354807

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Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
Reyes-Corral M, et al.
Journal of Pharmacology and Experimental Therapeutics, 369(1), 152-162 (2019)
Alexander Burashnikov et al.
Circulation. Arrhythmia and electrophysiology, 5(2), 400-408 (2012-02-11)
Several clinical trials have shown that vernakalant is effective in terminating recent onset atrial fibrillation (AF). The electrophysiological actions of vernakalant are not fully understood. Here we report the results of a blinded study comparing the in vitro canine atrial
László Drimba et al.
Journal of cardiovascular pharmacology, 60(2), 208-218 (2012-05-25)
High-fat diet and consequent metabolic syndrome (MS) can lead to elevated risk for cardiac arrhythmias. This preclinical study was to investigate if cicletanine (CIC) could produce cardioprotective effects in conscious rabbits exhibiting the main symptoms of MS. NZW rabbits that
Kyle A Arsenault et al.
The Cochrane database of systematic reviews, 1(1), CD003611-CD003611 (2013-02-27)
Atrial fibrillation is a common post-operative complication of cardiac surgery and is associated with an increased risk of post-operative stroke, increased length of intensive care unit and hospital stays, healthcare costs and mortality. Numerous trials have evaluated various pharmacological and
Wei Liu et al.
Pharmaceutical research, 29(7), 1768-1774 (2012-02-22)
To clarify sotalol's classification in the BCS versus BDDCS systems through cellular, rat everted sac and PAMPA permeability studies. Studies were carried out in Madin Darby canine kidney (MDCK) and MDR1-transfected MDCK (MDCK-MDR1) cell lines, rat everted gut sacs and
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