R0158
RepSox
≥98% (HPLC), solid, TGF-β RI kinase inhibitor
Synonym(s):
E-616452; 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | PLN 720.00 |
25 mg | Please contact Customer Service for Availability | PLN 2,900.00 |
About This Item
Empirical Formula (Hill Notation):
C17H13N5
CAS Number:
Molecular Weight:
287.32
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Product Name
RepSox, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
solid
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cccc(n1)-c2n[nH]cc2-c3ccc4ncccc4n3
InChI
1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChI key
LBPKYPYHDKKRFS-UHFFFAOYSA-N
Application
RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5).[1] It has also been used as a basal media component for culturing human Pluripotent stem cells.
Biochem/physiol Actions
RepSox Inhibits TGF-beta receptor signaling.
RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).
RepSox inhibits osteoclast differentiation, resorption in bone tissues and ovariectomy (OVX)‐induced osteoporosis (OP) through repression of the SMAD family member 3 (Smad3) and c-Jun N-terminal kinase (JNK) pathway/ activator protein 1 (AP-1) pathways.
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This Item | |||
|---|---|---|---|
| form solid | form solid | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >20 mg/mL | solubility DMSO: ≥20 mg/mL | solubility DMSO: ~20 mg/mL, H2O: insoluble | solubility DMSO: 10 mg/mL, clear |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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