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D1944

D4476

≥98% (HPLC), solid

Synonym(s):

4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

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Size/SKUAvailabilityPrice
1 mg
Please contact Customer Service for Availability
PLN 976.00
5 mg
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PLN 3,850.00
PLN 3,272.50

About This Item

Empirical Formula (Hill Notation):
C23H18N4O3
CAS Number:
301836-43-1
Molecular Weight:
398.41
MDL number:
MFCD28391149
UNSPSC Code:
12352200
PubChem Substance ID:
329798715
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid

PLN 976.00

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Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

light yellow

solubility

DMSO: ~20 mg/mL, H2O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4

InChI

1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)

InChI key

DPDZHVCKYBCJHW-UHFFFAOYSA-N

Application

D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.

Biochem/physiol Actions

D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).
D4476 may prevent or enhance apoptosis.[1] It triggers tumor suppressor p53 and impairs transcription factor E2F-1.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
218696I6410S8822
D4476 ≥98% (HPLC), solid

Sigma-Aldrich

D1944

D4476

Casein Kinase I Inhibitor, D4476 The Casein Kinase I Inhibitor, D4476, also referenced under CAS 301836-43-1, controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

218696

Casein Kinase I Inhibitor, D4476

ISCK03 ≥98% (HPLC), solid

Sigma-Aldrich

I6410

ISCK03

SB-525334 ≥98% (HPLC)

Sigma-Aldrich

S8822

SB-525334

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

crystalline solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ~20 mg/mL, H2O: insoluble

solubility

DMSO: 40 mg/mL

solubility

DMSO: ≥20 mg/mL, H2O: insoluble

solubility

DMSO: ≥20 mg/mL

color

light yellow

color

-

color

yellow

color

yellow

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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