MAK520

Monoamine Oxidase (MAO) Inhibitor Screening Kit

sufficient for 100 fluorometric tests

• Synonym(s): MAO-A Inhibitor Detection Kit
• NACRES: NA.84
• UNSPSC Code: 12161503

Properties

• Quality Segment: 100
• application(s): pharmaceutical
• detection method: fluorometric
• relevant disease(s): Alzheimer′s disease; Parkinson′s disease; depression; migraine disorder; schizophrenia; substance abuse; neurodegenerative disorders; neuropsychiatric diseases; neurological disorders
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

Monoamine oxidases (MAO) are a family of mitochondrial enzymes that catalyze the oxidative deamination of monoamines. Two isoforms of MAO exist, MAO-A and MAO-B, with different inhibitor selectivity and tissue distribution. MAO dysfunction is thought to be responsible for a number of neurological disorders. Unusually high or low levels of MAOs in the body have been associated with depression, schizophrenia, substance abuse, attention deficit disorder, migraines, and irregular sexual maturation. MAO inhibitors are one of the major classes of drug prescribed for the treatment of depression, Parkinson′s, and Alzheimer′s diseases.

Application

The kit is suitable for inhibitor screening and evaluation of MAO inhibitors.

Biochem/physiol Actions

The Monoamine Oxidase (MAO) Inhibitor Screening Kit provides a convenient fluorometric means to screen for MAO enzyme inhibitors. In the assay, MAO reacts with p-tyramine, a substrate for both MAO-A and MAO-B, resulting in the formation of H2O2, which is determined by a fluorometric method at λEx = 530 nm/λEm = 585 nm.

Features and Benefits

• Compatible with high-throughput handling systems.

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 2