L7527
Lipoprotein, very low density from human plasma
≥95% (SDS-PAGE), solution
Synonym(s):
Pre-β-lipoprotein, VLDL, Very low density lipoprotein
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About This Item
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biological source
human plasma
Quality Level
Assay
≥95% (SDS-PAGE)
form
solution
functional group
ester
phospholipid
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... APOB(338) , APOC2(344) , APOE(348)
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Biochem/physiol Actions
Inhibits DNA synthesis in lymphocytes activated by the nonspecific mitogen concanavalin A (Con A).
VLDL (Very low density lipoprotein) may be used to study the mechanisms and effects of very low density receptors (VLDLR). VLDL is used as a potential source of fatty acids that support cardiac energy metabolism. VLDL is often studied to differentiate its effects from those of chylomicrons.
Physical form
Solution in 150 mM NaCl and 0.01% EDTA, pH 7.4
Other Notes
View more information on lipoprotein function and lipid transport at www.sigma-aldrich.com/enzymeexplorer
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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M C Sampedro et al.
Biochemical and biophysical research communications, 285(2), 393-399 (2001-07-11)
Human very-low-density lipoprotein (VLDL) inhibits DNA synthesis in lymphocytes activated by the nonspecific mitogen concanavalin A (Con A). We studied the effects of VLDL on lymphocyte activation (IL-2 receptor expression), cell cycle progression, and production of IL-2 and of IL-4
Gwang-Woong Go et al.
The Yale journal of biology and medicine, 85(1), 19-28 (2012-03-31)
The LDLR family of proteins is involved in lipoproteins trafficking. While the role of LDLR in cardiovascular disease has been widely studied, only recently the role of other members of the LDLR proteins in lipoprotein homeostasis and atherosclerosis has emerged.
Samata Tiwari et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(5), 1079-1086 (2012-04-21)
Steady increase in the incidence of atherosclerosis is becoming a major concern not only in the United States but also in other countries. One of the major risk factors for the development of atherosclerosis is high concentrations of plasma low-density
You-Guo Niu et al.
Journal of lipids, 2011, 189876-189876 (2011-07-21)
The heart is a major consumer of energy and is able to utilise a wide range of substrates including lipids. Nonesterified fatty acids (NEFA) were thought to be a favoured carbon source, but their quantitative contribution is limited because of
Katsuyuki Nakajima et al.
Clinica chimica acta; international journal of clinical chemistry, 412(15-16), 1306-1318 (2011-05-03)
Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial hyperlipidemia. However, it has been shown over
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