K1632
Kininogen high molecular weight, Two Chain from human plasma
lyophilized powder
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| Size/SKU | Availability | Price |
|---|---|---|
0.1 mg | Please contact Customer Service for Availability | PLN 465.00 |
About This Item
Form:
lyophilized powder
Biological source:
human plasma
PLN 465.00
Please contact Customer Service for Availability
biological source
human plasma
Quality Segment
form
lyophilized powder
solubility
H2O: soluble 0.1 mg protein/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... KNG1(3827), KNG1 (includes EG:3827)
General description
HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein.[1]
High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex.
Biochem/physiol Actions
High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis.
High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets.[2]
Packaging
Package size based on protein content
Physical form
Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl
Preparation Note
Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin.
1 of 1
This Item | |||
|---|---|---|---|
| biological source human plasma | biological source human plasma | biological source human plasma | biological source - |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form powder |
| solubility H2O: soluble 0.1 mg protein/mL | solubility - | solubility water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless | solubility - |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. | UniProt accession no. |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... KNG1(3827), KNG1 (includes EG:3827)(3827) | Gene Information human ... HPX(3263) | Gene Information human ... FN1(2335) | Gene Information human ... KNG1 (includes EG:3827)(3827) |
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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