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Anti-Endothelin B Receptor antibody produced in rabbit

Name: Anti-Endothelin B Receptor antibody produced in rabbit
Brand: SIGMA
Price: 2570 PLN

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ET-B Receptor

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Pack Size	SKU	Availability	Price
50 μL		Please contact Customer Service for Availability	PLN 2,570.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00675241

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ICC, IHC (p)

Citations:

PLN 2,570.00

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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunocytochemistry: 4-11 μg/mL using human adrenal tissue, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-11 μg/mL using human adrenal tissue

UniProt accession no.

P24530

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This Item	E9780	AB3284	C2866
Sigma-Aldrich E9905 Anti-Endothelin B Receptor antibody produced in rabbit	Sigma-Aldrich E9780 Anti-Endothelin A Receptor antibody produced in rabbit	Sigma-Aldrich AB3284 Anti-Endothelin Receptor B Antibody	Sigma-Aldrich C2866 Anti-Cannabinoid Receptor 1 antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity purified immunoglobulin	antibody form affinity isolated antibody
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Gene Information human ... EDNRB(1910) mouse ... Ednrb(13618) rat ... Ednrb(50672)	Gene Information human ... EDNRA(1909) mouse ... Ednra(13617) rat ... Ednra(24326)	Gene Information human ... EDNRB(1910)	Gene Information human ... CNR1(1268) mouse ... Cnr1(12801) rat ... Cnr1(25248)
technique(s) immunocytochemistry: 4-11 μg/mL using human adrenal tissue, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-11 μg/mL using human adrenal tissue	technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3-16 μg/mL using human heart tissue	technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8-11 μg/mL
species reactivity human	species reactivity human	species reactivity rat	species reactivity human

Immunogen

synthetic peptide corresponding to the N-terminal extracellular domain of human endothelin B receptor, conjugated to KLH. The immunizing peptide has 79% homology with the mouse gene and 84% homology with the rat gene.

Application

Anti-Endothelin B Receptor antibody produced in rabbit is suitable for the following applications:

Immunocytochemistry at a concentration of 4-11μg/mL using human adrenal tissue
Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4-11μg/mL using human adrenal tissue
Western blotting
Immunofluorescence

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

EDNRB Endothelin receptor type B (ETB) is a protein encoded by the EDNRB gene in humans. It plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy.[1] It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences.

J Milara et al.

British journal of pharmacology, 161(7), 1599-1615 (2010-08-12)

Pulmonary arteries from smokers and chronic obstructive pulmonary disease patients show abnormal endothelium-dependent vascular reactivity. We studied the effect of cigarette smoke extract (CSE) on endothelin receptor B (ET(B) ) expression in human pulmonary artery endothelial cells (HPAECs) and its

Divergent effects of aging and sex on vasoconstriction to endothelin in coronary arterioles.

Amanda J Leblanc et al.

Microcirculation (New York, N.Y. : 1994), 20(5), 365-376 (2012-12-04)

The risk for cardiovascular disease increases with advancing age; however, the chronological development of heart disease differs in males and females. The purpose of this study was to determine whether age-induced alterations in responses of coronary arterioles to the endogenous

Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

Suhas Vasaikar et al.

BMC cancer, 18(1), 154-154 (2018-02-08)

Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in

Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma.

T Tanaka et al.

British journal of cancer, 110(4), 1027-1033 (2013-12-21)

The endothelin axis has been shown to have a pivotal role in several human malignancies. The aim of this study was to clarify the clinical importance of endothelin receptor type B (ETBR) in human oesophageal squamous cell carcinoma (OSCC). We

Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome.

Megan M Wenner et al.

The Journal of physiology, 589(Pt 19), 4671-4679 (2011-08-10)

Endothelin-1 is elevated in women with polycystic ovary syndrome (PCOS), and may play a role in the endothelial dysfunction associated with PCOS. Endothelin-1 binds two receptor subtypes, endothelin A (ET-A) and endothelin B (ET-B). We hypothesized that ET-A mediates vasoconstriction

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Global Trade Item Number

SKU	GTIN
E9905-50UL	04061837832253

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