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D5193

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

Synonym(s):

17-DMAG

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About This Item

Empirical Formula (Hill Notation):
C32H48N4O8
Molecular Weight:
616.75
NACRES:
NA.85
UNSPSC Code:
51102829


biological source

synthetic

Quality Segment

form

powder

color

dark red-purple to black

solubility

ethanol: ~10 mg/mL (lit.), DMSO: >25 mg/mL (lit.)

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

−20°C

General description

Chemical structure: benzenoid

Application

17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC)[1].

Biochem/physiol Actions

17-DMAG is a heat shock protein (HSP90) inhibitor. 17-DMAG is a more potent analog of geldanamycin. It inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.
17-DMAG is a more potent analog of geldanamycin. Inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Global Trade Item Number

SKUGTIN
D5193-1MG04061835543977

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