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D1064

Dihydrokainic acid

≥98% (HPLC), GLT-1 glutamate transporter inhibitor, powder

Synonym(s):

2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid

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10 mg
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PLN 1,180.00
PLN 1,003.00
50 mg
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PLN 4,200.00

About This Item

Empirical Formula (Hill Notation):
C10H17NO4
CAS Number:
52497-36-6
Molecular Weight:
215.25
UNSPSC Code:
12352106
PubChem Substance ID:
24277981
NACRES:
NA.77
MDL number:
MFCD03412037
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

PLN 1,003.00

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Product Name

Dihydrokainic acid, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O

InChI

1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

InChI key

JQPDCKOQOOQUSC-OOZYFLPDSA-N

Gene Information

human ... SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)
rat ... Slc1a2(29482), Slc1a3(29483)

Application

Dihydrokainic acid has been used as a glutamate transporter (GLT-1) inhibitor in the glutamate uptake assay of astrocytes[1] and glial cells.[2] It may be used as a GLT-1 inhibitor in Lateral habenula (LHb).

Biochem/physiol Actions

Dihydrokainic acid is a selective GLT-1 glutamate transporter inhibitor; weak inhibitor of AMPA/kainate glutamic acid receptors at high concentrations.
Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. At higher concentrations, dihydrokainate is a weak inhibitor of AMPA/kainate glutamic acid receptors.
Dihydrokainic favors neuronal cell death.[3] It modulates anxiety and depression behaviors.

Features and Benefits

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
K2389SML0075K0250
Dihydrokainic acid ≥98% (HPLC), powder

Sigma-Aldrich

D1064

Dihydrokainic acid

Kainic acid monohydrate ≥98% (HPLC), from Digenea simplex

Sigma-Aldrich

K2389

Kainic acid monohydrate

OBAA ≥98% (HPLC)

Sigma-Aldrich

SML0075

OBAA

Kainic acid monohydrate ≥99% (TLC)

Sigma-Aldrich

K0250

Kainic acid monohydrate

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99% (TLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: >10 mg/mL

solubility

H2O: >10 mg/mL

solubility

DMSO: ≥5 mg/mL at 60 °C

solubility

H2O: soluble

Gene Information

human ... SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)
rat ... Slc1a2(29482), Slc1a3(29483)

Gene Information

-

Gene Information

-

Gene Information

human ... GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901), SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000483154
0000483154
0000382368
0000382367
0000374645

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Judy-Fay Ferron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(31), 9850-9860 (2009-08-07)
Isoflurane is a widely used anesthetic which safely and reversibly induces deep coma and associated burst suppression (BS) electroencephalographic patterns. Here we investigate possible underlying causes for the state of cortical hyperexcitability which was recently shown to be one of
Rescue of glutamate transport in the lateral habenula alleviates depression-and anxiety-like behaviors in ethanol-withdrawn rats
Kang S, et al.
Neuropharmacology, 129(11), 47-56 (2018)
Katrien C K Poelaert et al.
mBio, 12(2) (2021-03-25)
Viruses, including members of the herpes-, entero-, and morbillivirus families, are the most common cause of infectious encephalitis in mammals worldwide. During most instances of acute viral encephalitis, neurons are typically the initial cell type that is infected. However, as
View All Related Papers

Global Trade Item Number

SKUGTIN
D1064-10MG04061833558492
D1064-50MG04061832081830

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