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C5857

CA-074 methyl ester

≥99% (TLC)

Synonym(s):

(L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester

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5 mg
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PLN 1,820.00
PLN 1,547.00

About This Item

Empirical Formula (Hill Notation):
C19H31N3O6
CAS Number:
147859-80-1
Molecular Weight:
397.47
NACRES:
NA.77
PubChem Substance ID:
329775104
UNSPSC Code:
12352108
MDL number:
MFCD03452890
Assay:
≥99% (TLC)
Form:
solid

PLN 1,547.00

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biological source

synthetic (organic)

Quality Segment

100

assay

≥99% (TLC)

form

solid

storage temp.

−20°C

SMILES string

CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC

InChI

1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1

InChI key

XGWSRLSPWIEMLQ-RQLZCWDZSA-N

Application

CA-074 methyl ester has been used as cathepsin B inhibitor in cardiomyocytes, HeLa cells[1] and human pancreatic cancer PANC-1 cells.

Biochem/physiol Actions

CA-074 methyl ester is a cell-permeable analog of CA-074. It is an inhibitor of cathepsin B especially the intracellular type. and undergoes intracellular transition into active CA-074 by the action of esterases. CA-074 methyl ester also inhibits cathepsin L.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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1 of 1

This Item
C5732205531205530
CA-074 methyl ester ≥99% (TLC)

Sigma-Aldrich

C5857

CA-074 methyl ester

CA-074 ≥98% (HPLC)

Sigma-Aldrich

C5732

CA-074

CA-074 Me CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.

Sigma-Aldrich

205531

CA-074 Me

CA-074 CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

205530

CA-074

assay

≥99% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

biological source

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ7083
MKCV4462
MKCS3393
MKCS0909
MKCN3559

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Articles

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

Global Trade Item Number

SKUGTIN
C5857-5MG04061833502563

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