C5743

Cilastatin sodium salt

powder, ≥98% (HPLC)

• Synonym(s): Cilastatin sodium
• Empirical Formula (Hill Notation): C₁₆H₂₅N₂NaO₅S
• CAS Number: 81129-83-1
• Molecular Weight: 380.43
• MDL number: MFCD30488996
• UNSPSC Code: 12352204
• EC Number: 279-694-4
• NACRES: NA.77

Properties

• Product Name: Cilastatin sodium salt, ≥98% (HPLC)
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: water: 10 mg/mL, clear, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: [Na+].S(C[C@H](N)C(=O)[O-])CCCC\C=C(/NC(=O)[C@@H]1C(C1)(C)C)\C(=O)O
• InChI: 1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1
• InChI key: QXPBTTUOVWMPJN-QBNHLFMHSA-M

Description

General description

Cilastatin sodium salt is off-white to yellowish-white, hygroscopic, amorphous compound. It is derivatized from heptenoic acid. Its molecular mass is 380.43 g.

Biochem/physiol Actions

Inhibitor of dehydropeptidase I

Inhibitor of the renal enzyme dehydropeptidase I and some bacterial zinc-containing β-lactamases. By these action, cilastatin suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)