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C5625

Sigma-Aldrich

Lithium carbamoylphosphate dibasic hydrate

≥85% (enzymatic)

Synonym(s):

CAP-Li2, Carbamoylphosphate dilithium salt, Carbamyl phosphate dilithium salt, Carbamyl phosphoric acid dilithium salt

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About This Item

Linear Formula:
NH2COOPO3Li2·xH2O
CAS Number:
1866-68-8
Molecular Weight:
152.89 (anhydrous basis)
Beilstein:
6128395
MDL number:
MFCD00038144
UNSPSC Code:
12161700
PubChem Substance ID:
24892798
NACRES:
NA.25

product name

Lithium carbamoylphosphate dibasic hydrate,

Assay

≥85% (enzymatic)

form

powder

quality

may contain ~25% free acid (determined by PNMR)

color

white

storage temp.

−20°C

SMILES string

[Li+].[Li+].NC(=O)OP([O-])([O-])=O

InChI

1S/CH4NO5P.2Li/c2-1(3)7-8(4,5)6;;/h(H2,2,3)(H2,4,5,6);;/q;2*+1/p-2

InChI key

TUHZSMCNIUXAIJ-UHFFFAOYSA-L

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Application

Carbamoylphosphate is used to study processes involving the mammalian urea cycle and nitrogen metabolism. Carbamoylphosphate is used as a substrate to identify and characterize ornithine transcarbamylase(s).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Rita Kretz et al.
Molecular genetics and metabolism, 106(3), 375-378 (2012-05-12)
Carbamoylphosphate synthetase 1 (CPS1) is the first enzyme of the urea cycle. CPS1 deficiency is a rare autosomal-recessively inherited disorder that can lead to life-threatening hyperammonemia. Since there is no reliable biochemical marker for this disease, diagnosis relies on molecular
Mauricio Díaz-Muñoz et al.
Current medicinal chemistry, 17(21), 2253-2260 (2010-05-13)
Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a one-carbon-unit transferring enzyme that synthesizes citrulline using ornithine and carbamoylphosphate as substrates. It is involved in the metabolic transformation of arginine and proline, and it participates in the urea cycle in vertebrates and
G Sainz et al.
European journal of biochemistry, 251(1-2), 528-533 (1998-03-10)
The pseudo-reverse reaction of Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase in which arsenate is first coupled to citrulline followed by elimination of carbamylarsenate has been studied. Arsenate and citrulline saturation curves are sigmoidal. The different responsiveness of the transcarbamoylase to isosteric
Maria M Adeva et al.
Metabolism: clinical and experimental, 61(11), 1495-1511 (2012-08-28)
Free ammonium ions are produced and consumed during cell metabolism. Glutamine synthetase utilizes free ammonium ions to produce glutamine in the cytosol whereas glutaminase and glutamate dehydrogenase generate free ammonium ions in the mitochondria from glutamine and glutamate, respectively. Ammonia
Ruurdtje Hoekstra et al.
The international journal of biochemistry & cell biology, 43(10), 1483-1489 (2011-07-06)
For bioartificial liver application, cells should meet the following minimal requirements: ammonia elimination, drug metabolism and blood protein synthesis. Here we explore the suitability of HepaRG cells, a human cell line reported to differentiate into hepatocyte clusters and surrounding biliary

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