The potency of Product C5269 (Clindamycin hydrochloride) exceeds 800ug of Clindamycin/mg.
C5269
Clindamycin hydrochloride
lincosamide antibiotic
Synonym(s):
(7S)-7-Chloro-7-deoxylincomycin hydrochloride, Cleocin
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10 MG
PLN 795.00
50 MG
PLN 2,680.00
100 MG
PLN 4,700.00
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10 MG
PLN 795.00
50 MG
PLN 2,680.00
100 MG
PLN 4,700.00
About This Item
Empirical Formula (Hill Notation):
C18H33ClN2O5S · HCl
CAS Number:
Molecular Weight:
461.44
Beilstein:
4070786
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85
Recommended Products
Quality Level
form
powder or crystals
impurities
≤13%
solubility
H2O: 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O
InChI
1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1
InChI key
AUODDLQVRAJAJM-XJQDNNTCSA-N
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General description
Chemical structure: macrolide
Application
Clindamycin is used to study bacterial infections, such as group B streptococcal disease, bacterial resistance and plasma protein binding.[1][2][3]
Used to study bacterial protein synthesis.
Biochem/physiol Actions
Clindamycin hydrochloride is highly effective against anaerobic species.[4]
Clindamycin is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex. It has antibacterial activity against Gram-positive cocci and antiprotozoal activity against Taxoplasma.
Other Notes
Antibacterial and antiprotozoal antibiotic of the lincosamide class.
Keep container tightly closed in a dry and well-ventilated place.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Lact. - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Customers Also Viewed
J Spízek et al.
Applied microbiology and biotechnology, 64(4), 455-464 (2004-02-06)
Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria. They may even be bactericidal at the higher concentrations that can be reached in vivo. Clindamycin is usually more
A Burian et al.
The Journal of antimicrobial chemotherapy, 66(1), 134-137 (2010-11-04)
although plasma protein binding (PPB) is accepted to be an essential factor in reducing antimicrobial activity, little is known about the underlying mechanisms. One possibility includes impaired penetration of an antimicrobial into bacterial cells in the presence of PPB. As
Anouk E Muller et al.
Antimicrobial agents and chemotherapy, 54(5), 2175-2181 (2010-02-24)
The study presented here was performed to determine the pharmacokinetics of intravenously administered clindamycin in pregnant women. Seven pregnant women treated with clindamycin were recruited. Maternal blood and arterial and venous umbilical cord blood samples were obtained. Maternal clindamycin concentrations
Michael C Jewett et al.
Molecular systems biology, 9, 678-678 (2013-06-27)
Purely in vitro ribosome synthesis could provide a critical step towards unraveling the systems biology of ribosome biogenesis, constructing minimal cells from defined components, and engineering ribosomes with new functions. Here, as an initial step towards this goal, we report
Nasim Farahmand et al.
Microorganisms, 9(8) (2021-08-28)
A selection of 36 commercial probiotic fermented dairy products from UK and Europe markets were evaluated for the numbers, types, and viability of Lactobacillus strains against the stated information on their packages. A comparative study was carried out on selectivity
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What is the potency of this product?
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What is the pH of an aqueous solution of Clindamycin hydrochloride, Product C5269?
1 answer-
The expected pH of a 100 mg/ml aqueous solution is from 3.0 to 5.5, per USP 31, p. 1796.
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You list the purity of Clindamycin hydrochloride, Product C5269, as determined by thin layer chromatography. Is it possible to determine purity by other chromatographic methods?
1 answer-
The USP 31 describes a liquid chromatographic method utilizing Clindamycin Hydrochloride and Lincomycin Hydrochloride standards. Other publications may be searched on PubMed, such as G. La Follette et al., J Chromatogr., Vol. 431 (No. 2), pp. 379-388 (1988).
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the antibiotic potency of Clindamycin hydrochloride, Product C5269?
1 answer-
We do not include the potency of the compound in our quality specifications. Please contact Sigma-Aldrich Technical Service for the availability of lot-specific potency from our supplier.
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