C231

CGP-20712A methanesulfonate salt

≥98% (HPLC), Inhibitor of lysyl oxidase, solid

• Synonym(s): (±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt
• Empirical Formula (Hill Notation): C₂₃H₂₅F₃N₄O₅ · CH₄O₃S
• CAS Number: 105737-62-0
• Molecular Weight: 590.57
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278787
• NACRES: NA.77
• MDL number: MFCD00798870
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Product Name: CGP-20712A methanesulfonate salt, solid, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to off-white
• solubility: H₂O: >10 mg/mL, DMSO: 100 mg/mL
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.Cn1cc(nc1-c2ccc(OCC(O)CNCCOc3ccc(O)c(c3)C(N)=O)cc2)C(F)(F)F
• InChI: 1S/C23H25F3N4O5.CH4O3S/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33;1-5(2,3)4/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33);1H3,(H,2,3,4)
• InChI key: VFPOVCXWKBYDNF-UHFFFAOYSA-N
• Gene Information: human ... ADRB1(153)

Description

Application

CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM)[1] and rat cardiac fibroblasts.[2] It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.[3]

Biochem/physiol Actions

CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.[1]

Legal Information

Sold exclusively with the permission of Ciba-Geigy.

Disclaimer

Product is hygroscopic

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)