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C1618

Cibenzoline succinate

≥98% (HPLC), solid

Synonym(s):

2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate, Cibenol, Cipralan, Exacor

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10 mg
Please contact Customer Service for Availability
PLN 841.00
PLN 714.85
50 mg
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PLN 2,650.00

About This Item

Empirical Formula (Hill Notation):
C18H18N2 ·C4H6O4
CAS Number:
100678-32-8
Molecular Weight:
380.44
NACRES:
NA.77
PubChem Substance ID:
24892426
UNSPSC Code:
12352200
MDL number:
MFCD00941423
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated

PLN 714.85

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Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to brown

solubility

H2O: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)CCC(O)=O.C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4

InChI

1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)

InChI key

XFUIOIWYMHEPIE-UHFFFAOYSA-N

General description

Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(−) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.

Biochem/physiol Actions

Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.
Cibenzoline succinate inhibits ATP-sensitive K+ channels; class IA antiarrhythmic.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML2141E5156C223
Cibenzoline succinate ≥98% (HPLC), solid

Sigma-Aldrich

C1618

Cibenzoline succinate

Solifenacin succinate ≥98% (HPLC)

Sigma-Aldrich

SML2141

Solifenacin succinate

Epinastine hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

E5156

Epinastine hydrochloride

Cirazoline hydrochloride solid

Sigma-Aldrich

C223

Cirazoline hydrochloride

form

solid

form

powder

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

-

solubility

H2O: ≥5 mg/mL

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 38 mg/mL

solubility

H2O: >35 mg/mL

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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