Skip to Content
Merck

Key Documents

View All Documentation

Skip To

B157

BQ-788

≥95%, endothelin-B (ETRB) blocker, solid

Synonym(s):

2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle, N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
200 μg
Please contact Customer Service for Availability
PLN 1,010.00

About This Item

Empirical Formula (Hill Notation):
C34H50N5NaO7
CAS Number:
156161-89-6
Molecular Weight:
663.78
UNSPSC Code:
12352200
PubChem Substance ID:
329773192
NACRES:
NA.32
MDL number:
MFCD00797882
Assay:
≥95%
Form:
solid
Quality level:
200

PLN 1,010.00

Please contact Customer Service for Availability
​
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

BQ-788, ≥95%, solid

Quality Level

200

assay

≥95%

form

solid

color

white

solubility

acetonitrile: 0.3 mg/mL, DMSO: 1.2 mg/mL, ethanol: 1.2 mg/mL, H2O: slightly soluble

storage temp.

−20°C

SMILES string

[Na+].CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N3[C@@H](C)CCC[C@H]3C)C([O-])=O

InChI

1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1

InChI key

QCVIFBRTTLMEOV-FUKQNADPSA-M

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
B150E5411L9167
BQ-788 ≥95%, solid

Sigma-Aldrich

B157

BQ-788

BQ-123 ≥99%, sodium salt, lyophilized powder

Sigma-Aldrich

B150

BQ-123

Enniatin B from Gnomonia errabunda, ≥95% (HPLC)

Sigma-Aldrich

E5411

Enniatin B

LWH-63 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

L9167

LWH-63 hydrochloride

form

solid

form

lyophilized powder

form

-

form

solid

assay

≥95%

assay

≥99%

assay

≥95% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

acetonitrile: 0.3 mg/mL, ethanol: 1.2 mg/mL, DMSO: 1.2 mg/mL, H2O: slightly soluble

solubility

-

solubility

DMSO: 10 mg/mL, ethanol: 10 mg/mL, methanol: 10 mg/mL

solubility

DMSO: ~10 mg/mL, H2O: insoluble

color

white

color

-

color

-

color

light brown

Application

BQ-788 has been used as a selective endothelin-B (ETRB) blocker in human airway smooth muscle cells (HASMCs),[1] uterine mesothelial cells (UtMCs)-derived vascular smooth muscle cells (VSMCs),[2] and human umbilical vein endothelial cells (HUVECs)[3]

Biochem/physiol Actions

Selective ETB endothelin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000519739
0000519739
0000496221
0000496221
0000488460

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Emilia Kansanen et al.
Molecular pharmacology, 92(4), 481-490 (2017-08-06)
Nitro-fatty acids are reactive signaling mediators that are formed when unsaturated fatty acids react with nitric oxide or nitric oxide-derived species. Nitro-fatty acids can modify specific signaling pathways via post-translational modifications of Cys residues in key regulatory proteins. One of
Zhuo Wang et al.
PloS one, 8(3), e58078-e58078 (2013-04-05)
Obstructive sleep apnoea (OSA) is a risk factor for cardiovascular disorders and in some cases is complication of pulmonary hypertension. We simulated OSA by exposing rats to cyclic intermittent hypoxia (CIH) to investigate its effect on pulmonary vascular endothelial dysfunction.
Lenyta Oliveira Gomes et al.
The Journal of pharmacy and pharmacology, 70(7), 893-900 (2018-03-24)
This study assessed the ability of endothelin-1 (ET-1) to evoke heat hyperalgesia when injected directly into the trigeminal ganglia (TG) of mice and determined the receptors implicated in this effect. The effects of TG ETA and ETB receptor blockade on
H Karaki et al.
Biochemical and biophysical research communications, 205(1), 168-173 (1994-11-30)
The effects of a peptide, BQ-788 [N-cis-2, 6-dimethyl-piperidinocarbonyl-L-gamma-methylleucyl-D-1- methoxycarbonyltryptophanyl-D-norleucine], on isolated blood vessel and small intestine were examined. In the rat aorta, BQ-788 antagonized the endothelium-dependent, ETB1 receptor-mediated relaxation due to endothelin (ET)-3 with EC50 of 3 microM. In the
Christophe Faisy et al.
Critical care (London, England), 15(5), R208-R208 (2011-09-15)
Lung inflation may have deleterious effects on the alveoli during mechanical ventilation. However, the consequences of stretch during excessive lung inflation on basal tone and responsiveness of human bronchi are unknown. This study was undertaken to devise an experimental model
View All Related Papers

Global Trade Item Number

SKUGTIN
B157-200UG04061833426203

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service