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B134

BMY 7378 dihydrochloride

≥98% (HPLC), solid

Synonym(s):

8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

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Pack SizeSKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
PLN 1,150.00

About This Item

Empirical Formula (Hill Notation):
C22H31N3O3 · 2HCl
CAS Number:
21102-95-4
Molecular Weight:
458.42
NACRES:
NA.77
PubChem Substance ID:
24278080
UNSPSC Code:
12352200
MDL number:
MFCD00153771
Assay:
≥98% (HPLC)
Form:
solid

PLN 1,150.00

Please contact Customer Service for Availability
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assay

≥98% (HPLC)

form

solid

color

white

solubility

H2O: >5 mg/mL

SMILES string

Cl.Cl.COc1ccccc1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O

InChI

1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H

InChI key

NIBOMXUDFLRHRV-UHFFFAOYSA-N

Gene Information

human ... ADRA1D(146), HTR1A(3350)

Biochem/physiol Actions

BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold with the permission of Bristol Myers Squibb Corporation.

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This Item
L9908B7148C3118
BMY 7378 dihydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

B134

BMY 7378 dihydrochloride

LY-294,002 hydrochloride solid, ≥98% (HPLC)

Sigma-Aldrich

L9908

LY-294,002 hydrochloride

Buspirone hydrochloride

Sigma-Aldrich

B7148

Buspirone hydrochloride

CPNQ ≥98% (HPLC), solid

Sigma-Aldrich

C3118

CPNQ

form

solid

form

solid

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

solubility

H2O: >5 mg/mL

solubility

DMSO: >5 mg/mL, H2O: insoluble

solubility

-

solubility

H2O: insoluble <2 mg/mL, DMSO: >5 mg/mL

color

white

color

white to off-white

color

-

color

brown

Gene Information

human ... ADRA1D(146), HTR1A(3350)

Gene Information

-

Gene Information

human ... HTR1A(3350)

Gene Information

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000214591
0000214591
0000100795
0000067919
0000012642

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Articles

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

M Yang et al.
Naunyn-Schmiedeberg's archives of pharmacology, 355(4), 438-446 (1997-04-01)
We have used the alpha1D-adrenoceptor selective antagonist, BMY 7378, the alpha1D-selective agonists, adrenaline and phenylephrine, the alpha1A-selective antagonists, (+)-niguldipine, SB 216469 and WB4101, and the non-subtype-selective alpha1-adrenoceptor antagonist, nemonapride, to investigate the presence of alpha1D-adrenoceptors in rat tissues at the
M Eltze et al.
European journal of pharmacology, 378(1), 69-83 (1999-09-09)
The affinity for functional alpha1-adrenoceptor subtypes of buspirone in comparison with its close structural analogs and selective alpha1D-adrenoceptor antagonists, BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]dec ane-7,9-dione) and MDL 73005EF (8-[2-(1,4-benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro+ ++[4.5]decane-7,9-dione), was determined, namely at subtype A in rat vas deferens and perfused
M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 268(1), 337-352 (1994-01-01)
The novel benzodioxopiperazines [4-(benzodioxan-5-yl)1-[2- (benzocyclobutane-1-yl)ethyl]piperazine] (S 14489), [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine)] (S 15535) and [4-(benzodioxan-5-yl)1-[2(indan-1-yl)ethyl]piperazine (S15931) competitively displaced the binding of [3H]-8-OH-DPAT at serotonin (5-HT)1A receptors with affinities (pKis) of 9.2, 8.8 and 8.9, respectively. These values compared favorably with those of the
View All Related Papers

Global Trade Item Number

SKUGTIN
B134-25MG04061833422175
B134-100MG04061833422168

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