A8981
AS-252424
≥98% (HPLC), solid
Synonym(s):
5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Sign In to View Organizational & Contract Pricing.
About This Item
Empirical Formula (Hill Notation):
C14H8FNO4S
CAS Number:
Molecular Weight:
305.28
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
Oc1cc(F)ccc1-c2ccc(\C=C3\SC(=O)NC3=O)o2
InChI
1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6+
InChI key
OYYVWNDMOQPMGE-WUXMJOGZSA-N
Biochem/physiol Actions
AS-252424 is a potent and selective phosphoinositide 3-kinase PI3Kγ inhibitor with IC50 = 30 nM in a mouse model.
AS-252424 is a potent and selective phosphoinositide 3-kinase PI3Kγ inhibitor.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Articles
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Rabea Müller et al.
Frontiers in cellular neuroscience, 7, 24-24 (2013-03-19)
In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S
Olga Ksionda et al.
PloS one, 13(5), e0193849-e0193849 (2018-05-26)
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer. Poly-chemotherapy with cytotoxic and genotoxic drugs causes substantial toxicity and more specific therapies targeting the underlying molecular lesions are highly desired. Perturbed Ras signaling is prevalent in T-ALL and
Vincent Pomel et al.
Journal of medicinal chemistry, 49(13), 3857-3871 (2006-06-23)
Class I phosphoinositide 3-kinases (PI3Ks), in particular PI3Kgamma, have become attractive drug targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan-2-ylmethylene thiazolidinediones as selective, ATP-competitive PI3Kgamma inhibitors. Structure-based design and X-ray crystallography of complexes formed
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A8981-25MG | 04061832433806 |
| A8981-5MG | 04061832433813 |