Skip to Content
Merck

Key Documents

View All Documentation

Skip To

A5736

ARC 239 dihydrochloride hydrate

≥98% (HPLC)

Synonym(s):

(2-[2-[4-(o-Methoxyphenyl)piperazin-1-yl]ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolinedione dihydrochloride hydrate

Sign In to View Organizational & Contract Pricing.

About This Item

Empirical Formula (Hill Notation):
C24H29N3O3·2HCl · xH2O
CAS Number:
67339-62-2
Molecular Weight:
480.43 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329770834
UNSPSC Code:
12352200
MDL number:
MFCD16875414
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: >5 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Cl.COc1ccccc1N2CCN(CC2)CCN3C(=O)c4ccccc4C(C)(C)C3=O

InChI

1S/C24H29N3O3.2ClH.H2O/c1-24(2)19-9-5-4-8-18(19)22(28)27(23(24)29)17-14-25-12-15-26(16-13-25)20-10-6-7-11-21(20)30-3;;;/h4-11H,12-17H2,1-3H3;2*1H;1H2

InChI key

KWVGFMWBNZTADI-UHFFFAOYSA-N

Application

ARC 239 is a potent α-adrenoceptor blocking drug, competitively antagonizing pressor responses to adrenaline and inhibiting pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium.

Biochem/physiol Actions

ARC 239 is a selective α-2B adrenergic blocker.
ARC 239 is a selective α-2B adrenergic blocker. Although ARC-239, like prazosin, also has some alpha-1 antagonist activity, it is used most commomly to differentiate alpha-2A/D from alpha-2B and alpha-2C subtypes rather than for any alpha-1 inhibition..

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML0178A8106G5793
ARC 239 dihydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

A5736

ARC 239 dihydrochloride hydrate

ARL-17477 dihydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0178

ARL-17477 dihydrochloride hydrate

Altanserin hydrochloride hydrate ≥98% (HPLC), solid

Sigma-Aldrich

A8106

Altanserin hydrochloride hydrate

GR 127935 hydrochloride hydrate >98% (HPLC), powder

Sigma-Aldrich

G5793

GR 127935 hydrochloride hydrate

form

powder

form

powder

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: >5 mg/mL

solubility

H2O: ≥5 mg/mL

solubility

DMSO: >5 mg/mL, H2O: insoluble

solubility

DMSO: 10 mg/mL, clear

color

white to off-white

color

white to beige

color

-

color

white to beige

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000499651
0000499651
109K4602V
0000080488
0000022793

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

α2-Adrenoceptory

Dowiedz się więcej o receptorze alfa-2 adrenergicznym i jego podtypach, pośredniczonych reakcjach i zastosowaniach agonistów. Zawiera listę dostępnych produktów i tabelę porównawczą.

α2-Adrenoceptors

Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.

L F Callado et al.
European journal of pharmacology, 366(1), 35-39 (1999-03-04)
In this study, we used subtype-selective antagonists to determine the subtype of alpha2-adrenoceptor controlling noradrenaline release in rat locus coeruleus. Noradrenaline release was measured in locus coeruleus slices using fast cyclic voltammetry at carbon fibre microelectrodes. On long stimulation trains
L Liu et al.
British journal of pharmacology, 120(5), 892-898 (1997-03-01)
1. The influence of the sympathetic nervous system on intestinal fluid transport by the jejunum and ileum of the anaesthetized rat was investigated under basal conditions and during active secretion induced by intra-arterial infusion of vasoactive intestinal peptide (VIP). 2.
M Taoda et al.
Neurochemistry international, 38(4), 317-322 (2001-01-04)
The presynaptic modulation of [3H]-noradrenaline (NA) release from rat kidney cortex slices, a method used for the first time, was investigated. Rat kidney cortex slices were loaded with [3H]-NA and the release of radioactivity at rest and in response to
View All Related Papers

Global Trade Item Number

SKUGTIN
A5736-5MG04061832079189

Questions

Reviews

No rating value

Active Filters