A4562

5-(N,N-Dimethyl)amiloride hydrochloride

cAMP-dependent protein kinase inhibitor, powder

• Synonym(s): 3-Amino-N-(aminoiminoethyl)-5-(dimethylamino)-6-chloropyrazinecarboxamide hydrochloride, DMA
• Empirical Formula (Hill Notation): C₈H₁₂ClN₇O · HCl
• CAS Number: 1214-79-5
• Molecular Weight: 294.14
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278216
• NACRES: NA.77
• MDL number: MFCD00069207
• Form: powder

Properties

• Product Name: 5-(N,N-Dimethyl)amiloride hydrochloride,
• form: powder
• Quality Segment: 200
• storage temp.: 2-8°C
• SMILES string: Cl.CN(C)c1nc(N)c(nc1Cl)C(=O)\N=C(\N)N
• InChI: 1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H
• InChI key: IIUPTHVVXMBJMQ-UHFFFAOYSA-N
• Gene Information: human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548) ; mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) ; rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)

Description

Application

5-(N,N-Dimethyl)amiloride hydrochloride is a selective blocker of Na²/H⁺ antiport. 5-(N,N-Dimethyl)amiloride hydrochloride has been investigated for its ability to reduce inflammatory pain.

Biochem/physiol Actions

Selective blocker of Na⁺/H⁺ antiport; IC₅₀ = 6.9 μM.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable