A3737

Cefepime hydrochloride

• Synonym(s): Cefepime dihydrochloride monohydrate
• Linear Formula: C₁₉H₂₅N₆O₅S₂Cl · HCl · H₂O
• CAS Number: 123171-59-5
• Molecular Weight: 571.50
• MDL number: MFCD01687679
• UNSPSC Code: 51282610
• NACRES: NA.85

Properties

• form: powder
• Quality Segment: 200
• color: white to faint yellow
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: cell wall synthesis | interferes
• storage temp.: −20°C
• SMILES string: [s]1c(nc(c1)\C(=N\OC)\C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)C[N+]4(CCCC4)C)N.[Cl-].[Cl-].O.[H+]
• InChI: 1S/C19H24N6O5S2.2ClH.H2O/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11;;;/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29);2*1H;1H2/b23-12-;;;/t13-,17-;;;/m1.../s1
• InChI key: LRAJHPGSGBRUJN-OMIVUECESA-N

Description

General description

Cefepime is a semi-synthetic fourth-generation cephalosporin. It is resistant to hydrolysis by common plasmid and/or chromosomally-mediated β-lactamases.[1]

Application

Cefepime was used in antimicrobial susceptibility testing for Acinetobacter baumannii[2] and extended-spectrum-β-lactamase-producing Escherichia coli[3] isolated from various samples.

Biochem/physiol Actions

Cefepime is a broad-spectrum cephalosporin with activity against Gram-positive and Gram-negative bacteria. It binds to penicillin-binding proteins and disrupts the cell wall synthesis.[1][4]

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable