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A2737

Atractylenolide I

≥98% (HPLC)

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Pack SizeSKUAvailabilityPrice
10 mg
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PLN 1,640.00
PLN 1,230.00

About This Item

Empirical Formula (Hill Notation):
C15H18O2
CAS Number:
73069-13-3
Molecular Weight:
230.30
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
MFCD09037395

PLN 1,230.00

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Quality Segment

100

assay

≥98% (HPLC)

form

powder or crystals

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

C=C1CCC[C@@](C=C2O3)(C)[C@@]1([H])CC2=C(C)C3=O

InChI

1S/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h8,12H,1,4-7H2,2-3H3/t12-,15+/m0/s1

InChI key

ZTVSGQPHMUYCRS-SWLSCSKDSA-N

General description

Atractylenolide I is one of the active ingredients of Rhizoma Atractylodes macrocephala which is obtained from the dried root and stem of Atractylodes Macrocephala Koidz. It is a sesquiterpene compound of hydrophobic nature.[1][2][3]

Application

Atractylenolide I is a phytochemical that may be used to study its anti-inflammatory and anti-angiogenesis activities. Atractylenolide I may be used and studied as a postitive modulator of GABA-induced chloride currents I(GABA) and as an inhibitor of aromatases. Atractylenolide I may be used as a reference material in assays to detect its presence in plant root extracts and biological milieu such as plasma.

Biochem/physiol Actions

Atractylenolide I has been reported to have an anti-inflammatory activity due to its inhibitory effect on tumor necrosis factor-α (TNF-α) and the production of nitric oxide (NO).[1] It also shows anti-cancer nature, thereby being used in the management of gastric cancer cachexia symptoms.[4] Additionally, it has anti-angiogenic[2], pro-oxidative and cytotoxic characteristics.[3]
Phytochemical from Traditional Chinese Medicine herbal preparations. Atractylenolide I is an anti-inflammatory that is reported to inhibit angiogenesis.

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This Item
PHL82480PHL82479A2987
Atractylenolide I ≥98% (HPLC)

Sigma-Aldrich

A2737

Atractylenolide I

Atractylenolide II phyproof® Reference Substance

PHL82480

Atractylenolide II

Atractylenolide I phyproof® Reference Substance

PHL82479

Atractylenolide I

Atractylenolide III ≥98% (HPLC)

Sigma-Aldrich

A2987

Atractylenolide III

assay

≥98% (HPLC)

assay

≥95.0% (HPLC)

assay

≥98.0% (HPLC)

assay

≥98% (HPLC)

form

powder or crystals

form

-

form

-

form

powder or crystals

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

food and beverages

application(s)

food and beverages

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

methanol: 1 mg/mL, clear, colorless

solubility

-

solubility

-

solubility

methanol: 1 mg/mL, clear, colorless

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

339.6 °F

flash_point_c

170.87 °C

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Certificates of Analysis (COA)

Lot/Batch Number
0000378862
0000378862
0000274581
0000274581
SLBR9622V

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Yi Liu et al.
Evidence-based complementary and alternative medicine : eCAM, 5(3), 337-344 (2008-10-03)
We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-6 (IL-6) and proteolysis-inducing factor
Judith Singhuber et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(3-4), 334-340 (2011-11-29)
Several Chinese herbal medicines (CHMs) are used in the treatment of insomnia, restlessness, or anxiety. However, mechanisms underlying this effect and scientific proof for their traditional use is scarce. In the present study CHMs were screened for their ability to
Hyun Young Park et al.
Planta medica, 77(13), 1528-1530 (2011-02-25)
The roots of Cyathula officinalis Kuan are widely used in Chinese medicine for the treatment of inflammatory disorders. Here, the ability of C. officinalis Kuan to downregulate matrix metalloproteinase (MMP)-13 was examined since MMP-13 is an important enzyme for the
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Global Trade Item Number

SKUGTIN
A2737-10MG04061833046821
A2737-50MG04061833046838

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