We have not tested the cell membrane permeability of Product 90790, L-α-Hydroxyglutaric acid disodium salt. A helpful reference discussing the use of L-α-Hydroxyglutaric acid disodium salt to treat zebrafish is listed below.Parng, C. et al., Neurotoxicology and Teratology, 28, 509-516 , (2006).
90790
L-α-Hydroxyglutaric acid disodium salt
≥98.0% (GC)
Synonym(s):
(S)-2-Hydroxypentanedioic acid disodium salt, Disodium (S)-2-hydroxyglutarate
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| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Please contact Customer Service for Availability | 416,00 PLN |
50 mg | Please contact Customer Service for Availability | 1.570,00 PLN |
About This Item
Linear Formula:
C5H6O5Na2
CAS Number:
Molecular Weight:
192.08
UNSPSC Code:
12352106
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5318042
Quality Segment
assay
≥98.0% (GC)
form
powder or crystals
optical activity
[α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
impurities
≤6.0% water
relevant disease(s)
cancer
storage temp.
2-8°C
SMILES string
[O-]C(CC[C@@H](C([O-])=O)O)=O.[Na+].[Na+]
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
InChI key
DZHFTEDSQFPDPP-QTNFYWBSSA-L
General description
Application
L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.
Biochem/physiol Actions
L-alpha-Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, leading to the metabolic disorder L-2-hydroxyglutaric aciduria (L-2HGA). L-2HGA is associated with neuronal defects, leukodystrophy and linked to an increased risk of brain tumors.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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This Item | |||
|---|---|---|---|
| description ≥98.0% (GC) | description analytical standard | description certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | description analytical standard |
| assay ≥98.0% (GC) | assay ≥98.0% (GC) | assay - | assay ≥95.0% (GC) |
| Quality Level 100 | Quality Level 100 | Quality Level 300 | Quality Level 100 |
| form powder or crystals | form - | form - | form - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| optical activity [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH | optical activity [α]/D -8.0±1.5°, c = 1 in 0.1 M NaOH | optical activity - | optical activity - |
| relevant disease(s) cancer | relevant disease(s) - | relevant disease(s) - | relevant disease(s) - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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Is Product 90790, L-α-Hydroxyglutaric acid disodium salt cell membrane permeable?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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