50847

Gramicidin C from Bacillus brevis

~90% (HPLC)

• CAS Number: 9062-61-7
• MDL number: MFCD00466945
• UNSPSC Code: 51283112
• NACRES: NA.85

Properties

• form: powder
• InChI key: IUAYMJGZBVDSGL-JYFSIOBESA-N
• SMILES string: CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@@H](Cc5ccccc5)NC1=O)C(C)C)C(C)C
• biological source: Bacillus brevis
• assay: ~90% (HPLC)
• impurities: ≤5% water
• color: white to off-white
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: cell membrane | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• Quality Level: 100

Description

General description

Chemical structure: peptide

Application

Gramicidin is a naturally occuring polypeptide antibiotic. It functions as a transmembrane ion channel and is used for studies on phospholipid bilayer membrane fluidity measured by lateral diffusion.

Biochem/physiol Actions

Gramicidin′s bactericidal activity is a result of increasing the permeability of the bacterial cell membrane. This allows inorganic monovalent cations to travel through unrestricted which thereby destroys the ion gradient between the cytoplasm and the extracellular environment [1].

Naturally occuring polypeptide antibiotic with Tyr at position 11; functions as a transmembrane ion channel.

Packaging

10mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place. Keep in a dry place.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)