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A115

Amitriptyline metabolite, (±)-E-10-hydroxylated-

analytical standard

Synonym(s):

(±)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

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Pack SizeSKUAvailabilityPrice
2 mg
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PLN 1,310.00

About This Item

Empirical Formula (Hill Notation):
C20H23NO
CAS Number:
64520-05-4
Molecular Weight:
293.40
NACRES:
NA.24
PubChem Substance ID:
329770681
UNSPSC Code:
41116107
MDL number:
MFCD00069200

PLN 1,310.00

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Quality Segment

200

grade

analytical standard

form

solid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white

mp

97-99 °C

solubility

0.1 M HCl: soluble, H2O: insoluble, methanol: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13

InChI

1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+

InChI key

GHWBJXOKAFHZAI-SFQUDFHCSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.

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This Item
SMB00969PHR13841029013
Amitriptyline metabolite, (±)-E-10-hydroxylated- analytical standard

Supelco

A115

Amitriptyline metabolite, (±)-E-10-hydroxylated-

(E)-10-Hydroxy amitriptyline ≥95% (HPLC)

Sigma-Aldrich

SMB00969

(E)-10-Hydroxy amitriptyline

Amitriptyline hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1384

Amitriptyline hydrochloride

Amitriptyline Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1029013

Amitriptyline Related Compound A

grade

analytical standard

grade

-

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

format

neat

format

-

format

neat

format

neat

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

form

solid

form

solid

form

-

form

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

solubility

0.1 M HCl: soluble, methanol: soluble, H2O: insoluble

solubility

-

solubility

-

solubility

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
FN06022219
FN10182301
FN04232005

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D R Jones et al.
Journal of chromatography, 278(2), 291-299 (1983-12-09)
A selective, sensitive method for the determination of amitriptyline and its metabolites is described. This method involves liquid-liquid extraction and capillary gas chromatography with nitrogen-sensitive detection. The detection limits of amitriptyline, nortriptyline, 10-hydroxy(E)amitriptyline, 10-hydroxy(E)nortriptyline, and 10-hydroxy(Z)nortriptyline were slightly less than
K Shimoda et al.
Journal of clinical psychopharmacology, 15(3), 175-181 (1995-06-01)
We measured the concentrations in plasma of amitriptyline and its metabolites, nortriptyline and geometric isomers of 10-hydroxynortriptyline and 10-hydroxyamitriptyline, in 73 Japanese psychiatric patients receiving amitriptyline hydrochloride (Tryptanol; Banyu Pharmaceutical Co. Ltd., Tokyo, Japan) by high-performance liquid chromatography. Although there
P Baumann et al.
International clinical psychopharmacology, 1(2), 102-112 (1986-04-01)
A subgroup of 16 out of 30 endogenous depressive inpatients (cf. part I), treated for 3 weeks with 150 mg amitriptyline (AT) daily, participated in a pharmacogenetic study: all were phenotyped with debrisoquine and 3 of them with mephenytoin. Four
View All Related Papers

Global Trade Item Number

SKUGTIN
A115-2MG04061833646144

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