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66930

N-Methyl-D-glucamine

ReagentPlus®, ≥99.0% (T)

Synonym(s):

1-Deoxy-1-(methylamino)-D-glucitol, Meglumine

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Size/SKUAvailabilityPrice
100 g
Please contact Customer Service for Availability
PLN 203.00
500 g
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PLN 587.00

About This Item

Empirical Formula (Hill Notation):
C7H17NO5
CAS Number:
Molecular Weight:
195.21
UNSPSC Code:
12352104
NACRES:
NA.22
PubChem Substance ID:
EC Number:
228-506-9
Beilstein/REAXYS Number:
385906
MDL number:

PLN 203.00


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biological source

synthetic

Quality Segment

product line

ReagentPlus®

assay

≥99.0% (T)

form

powder

optical activity

[α]20/D −16.5±0.5°, c = 2% in H2O

autoignition temp.

~662 °F

mp

126-131 °C, 129-131.5 °C (lit.)

solubility

H2O: 0.1 g/mL, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg, phosphate (PO43-): ≤5 mg/kg, sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤20 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

SMILES string

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1

InChI key

MBBZMMPHUWSWHV-BDVNFPICSA-N

General description

N-Methyl-D-glucamine, also known as Meglumine, is a sorbitol-derived amino sugar. It acts as a catalyst in one-pot synthesis of pyranopyrazole derivatives.

Application

N-Methyl-D-glucamine is utilized as:
  • An ion exchange resin due to its high affinity and selectivity for specific ions
  • A buffering agent to remove boron from an aqueous solution

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–2 of 2 Questions  
  1. What is the optimal volume of HCl to use in order to achieve a pH of 7.3 when using N-Methyl-D-glucamine (P/N: 66930) in a patch clamp solution without adding any additional Na+ ions?

    1 answer
    1. To neutralize 0.5 L of 120 mM 66930 solution, it is recommended to use 8 ml of 0.5 N HCl to adjust the pH to 8, and then dilute the HCl (e.g. 0.1 N) to titrate to pH 7.3. This approach can help avoid the drastic drop in pH.

      Helpful?

  2. When preparing a solution for patch clamping, what is the best optimal amount of HCL to use for ensuring that NaOH will not be required to maintain pH 7.3? F

    1 answer
    1. The necessary amount of HCl would need to be determined by the end-user. It is recommended to record the initial pH value prior to the addition of HCl. After recording the intial pH, add small increments of HCl (1-2 mL). The molarity of the HCL must also be considered when adding incremental volumes. A 1M HCl would be considered fairly dilute. Higher concentrations would require volume adjustments. Record the pH value after 5 minutes of stirring.

      For further questions or concerns, please navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.

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